Publications

2025

  • Frenster JD, Babin S, Josende Garcia JB, Casani-Galdon P, Pascual-Mas P, Robertson G, Garcia Ojalvo J, Martinez Arias A. “A mosaic gastruloid model highlights the developmental stage-specific restriction of cell competition in mammalian pre-gastrulation.” bioRxiv. 2025 Jan 2025.01.25.634859. (accepted in Nature Cell Biology)

  • Balayo T, Lunn S, Pascual-Mas P, Fiuza UM, Vasudevan A, Frenster JD, Josende Garcia JB, Galloon HY, Flores Peirats R, Martinez Arias A, Dias A, Turner DA. “N2B27 media formulations influence gastruloid development.” Development. 2025 Oct 152, dev204774

  • Wang AL, Bhattacharya A, Lee F, Mishkit O, Morales L, Tranos JA, Mao H, Rahman N, Frenster JD, Ravn-Boess N, Crook N, Wadghiri YZ, Placantonakis DG, Montclare JK. “A Modular Platform for Enhanced Drug Delivery to Glioblastoma using Targeted Multidomain Protein Assemblies.” Angew Chem Int Ed Engl. 2025 Jul 3:e202503085

2024

  • Stephan G, Haddock S, Wang S, Erdjument-Bromage H, Liu W, Ravn-Boess N, Frenster JD, Bready D, Cai J, Ronnen R, Sabio-Ortiz J, Fenyo D, Neubert T, Placantonakis DG. “Modulation of GPR133 (ADGRD1) Signaling by its Intracellular Interaction Partner Extended Synaptotagmin 1.” Cell Reports. 2024 May 16;43(5):114229

2023

  • Ravn-Boess N, Roy N, Hattori T, Bready D, Donaldson H, Lawson C, Lapierre C, Korman A, Rodrick T, Liu E, Frenster JD, Stephan G, Wilcox J, Corrado AD, Cai J, Ronnen R, Wang S, Haddock S, Sabio Ortiz J, Mishkit O, Khodadadi-Jamayran A, Tsirigos A, Fenyö D, Zagzag D, Drube J, Hoffmann C, Perna F, Jones DR, Possemato R, Koide A, Koide S, Park CY, Placantonakis DG. “The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability.” Cell Reports. 2023 Nov 28;42(11):113374.

  • Frenster JD, Erdjument-Bromage H, Liu W, Stephan G, Ravn-Boess N, Bready D, Wilcox J, Kieslich B, Jankovic M, Wilde C, Horn S, Sträter N, Liebscher I, Schöneberg T, Fenyo D, Neubert TA, Placantonakis DG. "PTK7 is a positive allosteric modulator of GPR133 (ADGRD1) signaling in glioblastoma." Cell Reports. 2023 Jun 23;42(7):112679

2022

  • Stephan G, Frenster JD, Liebscher I, Placantonakis DG. "Activation of the adhesion GPCR GPR133 (ADGRD1) by antibodies targeting the N-terminus." JBC. 2022 Jun;298(6):101949.

2021

  • Frenster JD, Stephan G, Ravn-Boess N, Bready D, Wilcox J, Kieslich B, Wilde C, Sträter N, Wiggin GR, Liebscher I, Schöneberg T, Placantonakis DG. "Functional impact of intramolecular cleavage and dissociation of adhesion G protein-coupled receptor GPR133 (ADGRD1) on canonical signaling." JBC. 2021 May 19:100798.

  • Yu JR, LeRoy G, Bready D, Frenster JD, Saldana-Meyer R, Jin Y, Descostes N, Stafford JM, Placantonakis DG, Reinberg D. “The H3K36me2 writer-reader dependency in H3K27M-DIPG.” Science Advances. 2021 Jul 14;7(29):eabg7444.

2020

  • Frenster JD, Kader M, Kamen MS, Sun J, Chiriboga L, Serrano J, Bready D, Golub D, Ravn-Boess N, Stephan G, Chi AS, Kurz SC, Jain R, Park CY, Fenyo D, Liebscher I, Schoneberg T, Wiggin GR, Newman R, Barnes M, Dickson JK, MacNeil DJ, Huang X, Shohdy N, Snuderl M, Zagzag D and Placantonakis DG. "Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes." Neurooncol Adv. 2020 Apr 28;2(1):vdaa053.

  • Frenster JD, Desai S, Placantonakis DG. "In vitro evidence for glioblastoma cell death in temperatures found in the penumbra of laser-ablated tumors." Int J Hyperthermia. 2020 Jul;37(2):20-26.

  • Cui X, Ma C, Vasudevaraja V, Serrano J, Tong J, Peng Y, Delorenzo M, Shen G, Frenster JD, Morales RT, Qian W, Tsirigos A, Chi AS, Jain R, Kurz CS, Sulman EP, Placantonakis DG, Snuderl M and Chen W. "Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy." Elife. 2020 Sep 10;9:e52253.

2019

  • Spino M, Kurz SC, Chiriboga L, Serrano J, Zeck B, Sen N, Patel S, Shen G, Vasudevaraja V, Tsirigos A, Suryadevara CM, Frenster JD, Tateishi K, Wakimoto H, Jain R, Riina HA, Nicolaides T, Sulman EP, Cahill DP, Golfinos JG, Isse K, Saunders LR, Zagzag D, Placantonakis DG, Snuderl M and Chi AS. "Cell surface Notch ligand DLL3 is a therapeutic target in isocitrate dehydrogenase mutant glioma." Clinical Cancer Research. 2019 Feb 15;25(4):1261-1271.

2018

  • Frenster JD and Placantonakis DG. "Establishing Primary Human Glioblastoma Tumorsphere Cultures from Operative Specimens." Methods Mol Biol. 2018;1741:63-69.

  • Inocencio J, Frenster JD and Placantonakis DG. "Isolation of Glioblastoma Stem Cells with Flow Cytometry." Methods Mol Biol. 2018;1741:71-79

  • Frenster JD, Inocencio J and Placantonakis DG. "Lentiviral Transduction of Primary Human Glioblastoma Cultures." Methods Mol Biol. 2018;1741:81-89.

  • Frenster JD and Placantonakis DG. "Bioluminescent In Vivo Imaging of Orthotopic Glioblastoma Xenografts in Mice." Methods Mol Biol. 2018;1741:191-198.

2017

  • Modrek AS, Golub D, Khan T, Bready D, Prado J, Bowman C, Deng J, Zhang G, Rocha PP, Raviram R, Lazaris C, Stafford JM, LeRoy G, Kader M, Dhaliwal J, Bayin NS, Frenster JD, Serrano J, Chiriboga L, Baitalmal R, Nanjangud G, Chi AS, Golfinos JG, Wang J, Karajannis MA, Bonneau RA, Reinberg D, Tsirigos A, Zagzag D, Snuderl M, Skok JA, Neubert TA and Placantonakis DG. "Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2." Cell Reports. 2017 Oct 31;21(5):1267-1280.

  • Bayin NS, Frenster JD, Sen R, Si S, Modrek AS, Galifianakis N, Dolgalev I, Ortenzi V, Illa-Bochaca I, Khahera A, Serrano J, Chiriboga L, Zagzag D, Golfinos JG, Doyle W, Tsirigos A, Heguy A, Chesler M, Barcellos-Hoff MH, Snuderl M and Placantonakis DG. "Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells." Oncotarget. 2017 May 23;8(39):64932-64953.

  • Frenster JD*, Inocencio JF*, Xu Z, Dhaliwal J, Alghamdi A, Zagzag D, Bayin NS and Placantonakis DG. "GPR133 Promotes Glioblastoma Growth in Hypoxia." Neurosurgery. 2017 Sep 1;64(CN_suppl_1):177-181. (*Co-First authorship)

2016

  • Bayin NS*, Frenster JD*, Kane JR, Rubenstein J, Modrek AS, Baitalmal R, Dolgalev I, Rudzenski K, Scarabottolo L, Crespi D, Redaelli L, Snuderl M, Golfinos JG, Doyle W, Pacione D, Parker EC, Chi AS, Heguy A, MacNeil DJ, Shohdy N, Zagzag D and Placantonakis DG. "GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth." Oncogenesis. 2016 Oct 24;5(10):e263. (*Co-First authorship)

  • Bustoros M, Thomas C, Frenster JD, Modrek AS, Bayin NS, Snuderl M, Rosen G, Schiff PB and Placantonakis DG. "Adult Primary Spinal Epidural Extraosseous Ewing's Sarcoma: A Case Report and Review of the Literature." Case Rep Neurol Med. 2016;2016:1217428.